Bone is a dynamic organ of the endoskeleton, playing an important role in structural integrity, mineral reservoirs, blood production,\ncoagulation, and immunity. Metabolic bone disease encompasses a broad spectrum of inherited and acquired disorders that\ndisrupt the normal homeostasis of bone formation and resorption. For patients affected by these processes, radiologic imaging\nplays a central role in diagnosis, monitoring treatment, and risk stratification. Radiologists should be familiar with the diseases,\nintimately aware of the imaging findings, and possessive of multimodality expertise to wisely guide the best practice of medicine.\nThe purpose of this paper is to review the imaging features and characteristics of the most common types of metabolic bone\ndisease with highlights of clinically relevant information so that readers can better generate appropriate differential diagnoses and\nrecommendations. For this review, a thorough literature search for the most up-to-date information was performed on several key\ntypes of metabolic bone disease: osteoporosis, osteomalacia, rickets, scurvy, renal osteodystrophy, hyperparathyroidism, Paget�s\ndisease, osteogenesis imperfecta, acromegaly, and osteopetrosis. Although they all affect the bone, these diseases have both shared\ncharacteristic features that can be discerned through imaging.
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